D/P-PALS showed significantly lower FA values than healthy controls in almost all regions, whereas P/S-PALS FA values were significantly lower only in the left precentral gray matter (GM), right precentral white matter (WM), cerebral peduncles (CP), left hemipons, and left bulbar pyramid (BP). H-MRS voxels were localized bilaterally in precentral regions. Anatomical areas were sampled by positioning regions of interest along corticospinal tracts, from the precentral cortex to the bulb. DTI indices included Fractional Anisotropy (FA) and averaged Apparent Diffusion Coefficient (avADC).
The subjects were subdivided into definite/probable (D/P) and possible/suspected (P/S).
We studied 32 PALS using Magnetic Resonance Imaging.
The aim of this study was to correlate brain DTI and MRS data with clinical parameters in ALS patients (PALS). Upper motor neuron (UMN) dysfunction in Amyotrophic Lateral Sclerosis (ALS) is not easy to identify clinically: Diffusion Tensor Imaging (DTI) and single-voxel Magnetic Resonance Spectroscopy (H-MRS) can identify markers of UMN involvement.
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